Mammalian Toxicology surveys chemical agents and examines how such
chemicals impact on human health, emphasizing the importance in
minimizing environmental exposure to chemical and physical hazards
in our homes, communities and workplaces through such media as
contaminated water, soil and air. Starting with the basic
principles on a wide range of toxic agents, this textbook describes
how they enter the body, their mechanisms of action once inside,
and strategies for diagnosis, prevention and treatment. Topics
covered include: *General principles of toxicology: pharmacological
and toxicological principles underpinning the study of toxicology,
risk assessments and mechanisms of cell death *Disposition: routes
of chemical exposures, entry into the body and various tissues,
storage, metabolic biotransformation and elimination, with examples
from various toxicants. *Toxic agents: the occurrences, disposition
in the body, health effects, toxic mechanisms, antidotes and
treatments of a range of agents including pesticides, metals,
solvents, gases, nanomaterials, food components and additives,
pharmaceuticals, drugs of abuse, natural toxins, endocrine
disruptors, radiation, and warfare weapons. *Toxic effects:
including neurotoxicity, developmental toxicity, immunotoxicity,
teratogenecity, male and female reproductive toxicity,
mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular
toxicity, hepatotoxicity, gastrointestinal toxicity and
cardiovascular toxicity *Toxicology and society: epidemiological
studies of chemical-induced diseases in human populations, and a
vision for toxicology in the 21st century. Mammalian Toxicology is
an essential primer for students of toxicology, biochemistry,
biology, medicine and chemistry. It is also appropriate for
professional toxicologists in research or regulatory affairs, and
anyone who needs to understand the adverse effects of toxic agents
on the human body.
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