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Books > Medicine > Clinical & internal medicine > Haematology
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Red Cell Shape - Physiology, Pathology, Ultrastructure (Paperback, Softcover reprint of the original 1st ed. 1973)
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Red Cell Shape - Physiology, Pathology, Ultrastructure (Paperback, Softcover reprint of the original 1st ed. 1973)
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This monograph is a collection of invited contributions from a
group of investiga tors who share a common interest in the
interrelationships between the shape, struc ture, and functional
characteristics of normal and pathologic erythrocytes. Most of the
authors participated in a workshop on red cell shape held in June,
1972 at the Institute of Cell Pathology, Hopital de Bicetre, Paris.
We hope that these various contributions on the physiology,
pathology, and ultrastructure of red cell shape will be useful and
stimulating for other investigators interested in the correlation
of shape and structure with the biochemistry and biophysics of the
red cell. The text is divided into four sections. Section I deals
with red cell shape, including the presentation of a rational
descriptive nomenclature and a discussion of post splenectomy
changes. Section II deals with biochemical factors that underlie
the disco cyte-echinocyte (crenated) and discocyte-stomatocyte
(cup-shaped) transformation. This section includes discussions of
plasma factors, and of the biochemical dynamics of erythrocyte
lipids and consideration of the effects of such factors as cellular
ATP, calcium, aging, and various chemical agents as determinants of
shape. Section III, which deals with biophysical measurements,
includes studies of the deformability of cells of different shapes,
descriptions of ways to define precisely the geometric dimensions
of the red cell under various circumstances, and a model of
membrane structure, which is proposed to account for the dimensions
of red cells that undergo shape change."
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