Of the two disciplines in parallel development for two decades,
tumor immunology and transplantation immunology, the latter has
thrived and has led to some of the most critical discoveries in
immunobiology. The former continues to thwart both scientists and
clinicians alike.
The goal of immunologists in modern day research is to develop a
simple and effective means to manipulate cancer "in vivo, "
possibly encompassing several venues: identifying a phenotypic
marker and the use of either active or passive immunization;
include the use of passive reagents carrying "warheads" to
selectively destroy cancer cells; or altering the basic process of
cell survival.
This excellent multidiscipline-authored volume presents a theme
which has not been well described before. The papers include both
basic and clinical science and range from sophisticated molecular
biology to little more than phenomenology (e.g. the increased
association of cancer in some autoimmune diseases and increased
presentation of autoimmune phenomena in malignant condition). This,
however, is state-of-the-art.
This collection of themes will be of use not only to bench
scientists, but also to clinicians who treat patients. The book
represents progress at the cutting edge of this discipline, and
points the way to further developments in the "black box" of
immunology.
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