In the last few years, increasing effort has been devoted to
better define the characteristics of tissue damage occurring
outside MRI-visible lesions in patients with multiple sclerosis
(MS) and, as a consequence, to improve our understanding of the
disease pathobiology and of the mechanisms leading to the
accumulation of irreversible disability. This book provides an
updated review of the results obtained by leading research groups
in this field. The potential clinical applications of what has been
shown so far, as well as the areas for future research in the study
of normal-appearing white and gray matter damage in MS are
extensively discussed, making this book a valuable tool for
clinical neurologists who are involved in the daily-life care of MS
patients and for neuroscientists involved in MS research.
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