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Congenital Adrenal Hyperplasia (Paperback, Softcover reprint of the original 1st ed. 1984) Loot Price: R3,068
Discovery Miles 30 680
Congenital Adrenal Hyperplasia (Paperback, Softcover reprint of the original 1st ed. 1984): M.I. New, L S Levine

Congenital Adrenal Hyperplasia (Paperback, Softcover reprint of the original 1st ed. 1984)

M.I. New, L S Levine

Series: Monographs on Endocrinology, 26

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Loot Price R3,068 Discovery Miles 30 680 | Repayment Terms: R288 pm x 12*

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Congenital adrenal hyperplasia (CAH) consists of a group of disorders of adrenal steroidogenesis. Each disorder results from an inherited deficiency of one of the several enzymes necessary for normal steroid synthesis. The different enzyme deficiencies produce characteristic patterns of hormonal abnormalities; the clinical symptoms of the different forms of CAH depend on the particular hormones that are deficient or that are produced in excess. The earliest documented description of CAH was by DeCrecchio in 1865 (DeCrecchio 1865). This Neapolitan anatomist described a cadaver having a penis with first degree hypospadias but no externally palpable gonads. Dis- section revealed a vagina, uterus, fallopian tubes, ovaries, and markedly enlarged adrenals. It is interesting that the subject suffered a confusion of sex assignment, being declared a female at birth and a male 4 years later. He conducted himself as a male sexually and socially. Since the original descrip- tion of this case, investigators have unravelled the pathophysiology of the inborn errors of steroidogenesis. 1 Steroidogenesis and Enzymatic Conversions of Adrenal Steroid Hormones A. Steroidogenesis The adrenal synthesizes three main classes of hormones: mineralocorticoids (17-deoxy pathway), glucocorticoids (17-hydroxy pathway), and sex steroids.

General

Imprint: Springer-Verlag
Country of origin: Germany
Series: Monographs on Endocrinology, 26
Release date: December 2011
First published: 1984
Authors: M.I. New • L S Levine
Dimensions: 244 x 170 x 5mm (L x W x T)
Format: Paperback
Pages: 90
Edition: Softcover reprint of the original 1st ed. 1984
ISBN-13: 978-3-642-82013-7
Categories: Books > Medicine > Clinical & internal medicine > Endocrinology > General
Books > Medicine > Clinical & internal medicine > Renal medicine > General
Books > Medicine > Clinical & internal medicine > Gynaecology & obstetrics > General
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LSN: 3-642-82013-1
Barcode: 9783642820137

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