This book summarizes recent advances in understanding the mechanism
underlying the selective cell death of dopamine neurons in
Parkinson's disease. MPTP, endogenous neurotoxins, L-DOPA, and
metal were proved to induce apoptosis and necrosis in neurons. The
relationship of these causal factors to the pathogenesis of
Parkinson's disease was discussed to give us overviews on the role
of neurotoxins in this degenerative disorder. This title further
presents the intracellular signal transduction, and the related
enzymes and other factors involved in dopaminergic neuronal death.
Recent results on intracellular mechanism of neuroprotection are
presented, suggesting that neuroprotection as a causal therapy of
neurodegenerative disorders may become practical in near future.
This book shows new neuroprotective agents, such as propargylamine
derivatives and neurotrophins, and the intracellular mechanism to
prevent the activation of apoptotic cascade in neurons. The authors
of this book are active researchers participating in these subjects
and the readers will find the knowledge and techniques for the
study on neurotoxicity and neuroprotection, and the strategy for
future research on these important subjects in clinical and basic
neurology and neurosciences.
The book is dedicated to Professor Toshiharu Nagatsu, a pioneer in
the search for pathogenic factors in Parkinson's disease. The book
is reprinted from the journal 'Neurotoxicology and Teratology',
Volume 24/5.
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