Experts in the fields of energy metabolism, aging and oxidative
stress provide an integrated view of how mechanisms involved in
regulating energy metabolism are linked to fundamental processes of
aging including cellular stress resistance and free radical
production.
During evolution signal transduction pathways and organ systems
have been optimised for the efficient seeking, ingestion, storing
and using of energy. These signalling pathways play prominent roles
in lifespan determination with insulin and related signalling
pathways being prime examples. The authors consider how lifespan
and healthspan can be extended through knowledge of energy
metabolism with the experimental model of dietary restriction being
one example. The information in this volume of ACAG will foster
novel approaches and experiments for further understanding the
roles of energy metabolism in aging and disease.
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