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Protein Reviews - Purinergic Receptors - Volume 20 (Hardcover, 1st ed. 2019)
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Protein Reviews - Purinergic Receptors - Volume 20 (Hardcover, 1st ed. 2019)
Series: Protein Reviews, 1111
Expected to ship within 10 - 15 working days
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The Protein Reviews series serves as a publication vehicle for
reviews that focus on crucial contemporary and vital aspects of
protein structure, function, evolution and genetics. Volume 20,
Purinergic Receptors, has ten chapters. The first five chapters
deal with various aspects of membrane binding. The first chapter
focuses on the phox-homology (PX) domain, which is a
phosphoinositide-binding domain conserved in all eukaryotes and
present in forty-nine human proteins. The next chapter deals with
the modeling of PH domains/phosphoinositides interactions. This is
followed by a chapter on BAR domain proteins regulate Rho GTPase
signaling. The BAR (Bin-Amphiphysin-Rvs) domain is a membrane lipid
binding domain present in a wide variety of proteins, often
proteins with a role in Rho-regulated signaling pathways. The
fourth article presents AP180 N-terminal homology (ANTH) and Epsin
N-terminal homology (ENTH) domains and discusses their
physiological functions and involvement in disease. The fifth
article reviews the polyphosphoinositide-binding domains and
presents insights from peripheral membrane and lipid-transfer
proteins. This is followed by a chapter on the physiological
functions of phosphoinositide-modifying enzymes and their
interacting proteins in Arabidopsis, then by a chapter on the
molecular mechanisms of Vaspin action in various tissues such as
adipose tissue, skin, bone, blood vessels, and the brain. The
eighth chapter deals with exceptionally selective substrate
targeting by the metalloprotease anthrax lethal factor followed by
an article on Salmonella, E. coli, and Citrobacter type III
secretion system effector proteins that alter host innate immunity.
The last chapter presents New techniques to study intracellular
receptors in living cells, with insights into RIG-I-like receptor
signaling. Volume 20 is intended for research scientists,
clinicians, physicians and graduate students in the fields of
biochemistry, cell biology, molecular biology, immunology and
genetics.
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