Acute Lymphoblastic Leukemia (All) and Interferon Beta-1 Gene (Paperback)

Acute lymphoblastic leukemia (ALL) is a malignant disease caused by the abnormal growth and development of early non-granular white blood cells, or lymphoblasts. ALL occurs predominantly in children, peaking at 4 years of age. Interferons (IFNs) are the biological agents involved in the antiviral responses and the inhibition of tumor growth. In oncology, the IFNs are an important treatment options for a number of solid tumors and hematological malignancies. The IFN- 1gene consists of 840 bp and it lacks intron sequences. Seventy patients suffering from Childhood Acute Lymphoblastic Leukemia were studied and analyzed for mutation analysis of IFN- 1. So, 58.3% of the patients suffering from ALL were observed and compared with 41.7% normal DNA samples as control. PCR was performed and amplified gene products were detected on agarose gel and PAGE. Finally, SSCP was performed and mobility shift was observed in 7 out of 70 ALL samples. We observed that ALL disease typically develops in children ages 1-10 years old and is more prevalent in males than females. Mutation in the IFN- 1 gene was significantly related to 1-5 years in case of association of mutation with age.

General

Imprint:	Lap Lambert Academic Publishing
Country of origin:	Germany
Release date:	August 2012
First published:	August 2012
Authors:	Madiha Kanwal • Muhammad Jawad Khan • Abdul Rauf Shakoori
Dimensions:	229 x 152 x 10mm (L x W x T)
Format:	Paperback - Trade
Pages:	172
ISBN-13:	978-3-659-23041-7
Categories:	Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > General
LSN:	3-659-23041-3
Barcode:	9783659230417

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