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Topics in Modelling of Clustered Data (Paperback)
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Topics in Modelling of Clustered Data (Paperback)
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Many methods for analyzing clustered data exist, all with
advantages and limitations in particular applications. Compiled
from the contributions of leading specialists in the field, Topics
in Modelling of Clustered Data describes the tools and techniques
for modelling the clustered data often encountered in medical,
biological, environmental, and social science studies. It focuses
on providing a comprehensive treatment of marginal, conditional,
and random effects models using, among others, likelihood,
pseudo-likelihood, and generalized estimating equations methods.
The authors motivate and illustrate all aspects of these models in
a variety of real applications. They discuss several variations and
extensions, including individual-level covariates and combined
continuous and discrete outcomes. Flexible modelling with
fractional and local polynomials, omnibus lack-of-fit tests,
robustification against misspecification, exact, and bootstrap
inferential procedures all receive extensive treatment. The
applications discussed center primarily, but not exclusively, on
developmental toxicity, which leads naturally to discussion of
other methodologies, including risk assessment and dose-response
modelling. Clearly written, Topics in Modelling of Clustered Data
offers a practical, easily accessible survey of important modelling
issues. Overview models give structure to a multitude of
approaches, figures help readers visualize model characteristics,
and a generous use of examples illustrates all aspects of the
modelling process.
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