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Targeted Therapies in Cancer - An Update (Hardcover)
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Targeted Therapies in Cancer - An Update (Hardcover)
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Besides surgery, radiation therapy, endocrine therapy or
chemotherapy, which were widely used in cancer patients for
decades, the 21st century has seen the emergence of "targeted"
therapy, resulting from the identification of molecular pathways in
cells and their alterations in tumors. An increasing number of
compounds targeting specific molecules or cancer cells have been
developed and, for some of them, approved by the United States Food
and Drug Administration (FDA) as well as other regulators in EU and
Japan Additional new and more efficient types of compounds, are
still in clinical trials, but are expected to gain future approval.
More than eighty FDA-approved targeted therapies are described
here, along with about eighty other promising compounds. These
drugs are members of various therapy classes, including tyrosine
kinase inhibitors; serine/threonine kinase inhibitors; dual
specificity kinase inhibitors; lipid kinase inhibitors; poly ADP
ribose polymerase inhibitors; monoclonal antibodies; microtubule
targeting agents; histone deacetylase inhibitors; proteasome
inhibitors; antimetabolites; immunomodulatory agents; DNA
methyltransferase inhibitors; hedgehog pathway inhibitors; enzymes;
protein translation inhibitors; vaccines, oncolytic viruses;
chimeric antigen receptor T-cells (CAR-T); and so on. A series of
"companion" diagnostics intended to be used as an indication for
specific therapies, and approved to this aim are also mentioned.
The book aims to present the broad landscape of compounds and
companion diagnostics that are expected to pave the way towards a
future of hope for cancer patients.
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