Preclinical Drug Development (Hardcover, 2nd edition)

Preclinical Drug Development, Second Edition discusses the broad and complicated realm of preclinical drug development. Topics range from assessment of pharmacology and toxicology to industry trends and regulatory expectations to requirements that support clinical trials. Highlights of the Second Edition include: Pharmacokinetics Modeling and simulation Formulation and routes of administration Toxicity evaluations The assessment of drug absorption and metabolism Interspecies scaling Lead molecule selection and optimization via profiling Screening using in silico and in vitro toxicity evaluations The book also includes case studies on preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development, a review of ICH preclinical guidelines, and experimental methods used to study membrane drug transport and metabolism. This guide is a fundamental resource for medicinal chemists, biologists, and other specialists in the drug development sciences.

General

Imprint:	Crc Press
Country of origin:	United States
Series:	Drugs and the Pharmaceutical Sciences
Release date:	September 2009
First published:	2010
Editors:	Mark Rogge • David R. Taft
Dimensions:	254 x 178 x 28mm (L x W x T)
Format:	Hardcover
Pages:	380
Edition:	2nd edition
ISBN-13:	978-1-4200-8472-6
Categories:	Books > Science & Mathematics > Biology, life sciences > General Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
LSN:	1-4200-8472-0
Barcode:	9781420084726

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