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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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G Protein-Coupled Receptors in Drug Discovery - Methods and Protocols (Paperback, Softcover reprint of the original 2nd ed. 2015)
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G Protein-Coupled Receptors in Drug Discovery - Methods and Protocols (Paperback, Softcover reprint of the original 2nd ed. 2015)
Series: Methods in Molecular Biology, 1335
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This detailed volume provides an overview of recent techniques
employed in the field of G protein-coupled receptors (GPCRs) to
screen for new drugs and to derive information about their receptor
structure, dynamics, and function for the purpose of developing
improved therapeutics. Owing to remarkable recent advances in the
structural, biophysical and biochemical analyses of these
receptors, as well as a growing body of evidence hinting at the
possible relevance of allosteric modulators, biased agonists and
oligomer-selective ligands as improved therapeutic agents, drug
discovery for GPCRs has recently taken a completely new direction.
For this book, expert contributors have shared their protocols and
views on the impact of these methodologies on modern drug
discovery. Written for the highly successful Methods in Molecular
Biology series, chapters include introductions to their respective
topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols and tips on
troubleshooting and avoiding known pitfalls. Practical and fully
updated, G Protein-Coupled Receptors in Drug Discovery: Methods and
Protocols, Second Edition serves as an ideal guide for a diverse
audience from structural and molecular biologists to
pharmacologists and drug designers who wish to explore this
extensive class of key drug targets.
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