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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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G Protein-Coupled Receptors - Modeling and Simulation (Hardcover, 2014 ed.)
Loot Price: R4,943
Discovery Miles 49 430
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G Protein-Coupled Receptors - Modeling and Simulation (Hardcover, 2014 ed.)
Series: Advances in Experimental Medicine and Biology, 796
Expected to ship within 12 - 17 working days
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G protein-coupled receptors (GPCRs) are heptahelical transmembrane
receptors that convert extra-cellular stimuli into intra-cellular
signaling, and ultimately into biological responses. Since GPCRs
are natural targets for approximately 40% of all modern medicines,
it is not surprising that they have been the subject of intense
research. Notwithstanding the amount of data generated over the
years, discovering ligands of these receptors with optimal
therapeutic properties is not straightforward and has certainly
been hampered for years by the lack of high-resolution structural
information about these receptors. Luckily, there has been a steady
increase of high-resolution crystal structures of these receptors
since 2007, and this information, integrated with dynamic
inferences from computational and experimental methods, holds great
potential for the discovery of new, improved drugs. This book,
which provides, for the first time, state-of-the-art views on
modeling and simulation of GPCRs, is divided into 4 parts. In the
first part, the impact of currently available GPCR crystal
structures on structural modeling is discussed extensively as are
critical insights from simulations in the second part of the book.
The third part reports recent progress in rational ligand discovery
and mathematical modeling, whereas the fourth part provides an
overview of bioinformatics tools and resources that are available
for GPCRs.
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