Oligonucleotides are short sequences of nucleotides (RNA or DNA),
typically with twenty or fewer bases. Automated synthesisers allow
the synthesis of oligonucleotides up to 160 to 200 bases. The
length of a synthesised base is usually denoted by 'mer' (from
'Greek' meros "part"). For example, a fragment of 25 bases would be
called a 25-mer. Oligonucleotides are often used as probes for
detecting complementary DNA or RNA because they bind readily to
their complements. Examples of procedures that use oligonucleotides
are DNA microarrays, Southern blots, fluorescent in situ
hybridisation (FISH), and the synthesis of artificial genes. This
book brings together leading research in the field from around the
globe.
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