Delayed tissue repair is a serious complication of long-term
diabetes mellitus. Prior to this study there was no clear evidence
as to how diabetes changes skin microvascular blood flow or how
these changes influence tissue repair processes in early diabetes.
The research undertaken within this project aimed to investigate
the factors that are known to cause long-term vascular
complications of diabetes and how these factors contribute to early
changes in skin microvascular blood flow. The treatment protocols
used in this work showed that the action of these factors is
reversible in the early stages of diabetes. These same treatments
were also effective in improving the repair processes in our model
of diabetes. This research raised the possibility that early
intervention could prevent microvascular alterations. The
information in this book could have significant clinical
implications for treating diabetic patients with long-term vascular
complications. The results of this study showed a significant
improvement in tissue repair processes using the principle of
non-invasive and easy to apply treatment protocols, which is worthy
of further investigation by medical researchers.
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