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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases
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Coxsackieviruses - A General Update (Paperback, Softcover reprint of the original 1st ed. 1988)
Loot Price: R1,732
Discovery Miles 17 320
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Coxsackieviruses - A General Update (Paperback, Softcover reprint of the original 1st ed. 1988)
Series: Infectious Agents and Pathogenesis
Expected to ship within 10 - 15 working days
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It is now just 40 years since coxsackieviruses were first isolated
by Dalldorf and Sickles in the "eponymous" town of Coxsackie, New
York. Yet the overall contribution of coxsackieviruses to
clinically evident dis ease of humans is still largely an open
problem. Following their discov ery, coxsackieviruses were under
intense clinical and laboratory scrutiny for a long time. Because
of their relationship to polioviruses, the under standing of their
structure, biochemistry, biology, and epidemiology ad vanced
rapidly as a result of the formidable efforts that eventually led
to the defeat of poliomyelitis. The ability of these viruses to
infect mice permitted dissection of their pathogenicity in an
experimental host and elucidation of conditions that influence its
expression. Coxsackieviruses have been progressively associated
with an increasing array of widely diverse human diseases. However,
only some of the suggested causal correlations have been
substantiated with satisfactory certainty. For others, conclusive
evidence has so far resisted investigation. Most impor tant, among
the latter are chronic maladies, such as dilated car diomyopathy
and juvenile diabetes, that demand consideration. In recent times,
there has been a partial eclipse of the subject of coxsackieviruses
in the medical literature. In addition to the difficulties
encountered in pinpointing their pathogenic potential, possible
reasons include the general decline of interest in enteroviruses,
which ensued after the conquest of poliomyelitis, and the
continuous appearance in the limelight of new, more esoteric, and
therefore more "appealing" viruses."
General
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