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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Nuclear Pore Complexes in Genome Organization, Function and Maintenance (Hardcover, 1st ed. 2018)
Loot Price: R4,263
Discovery Miles 42 630
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Nuclear Pore Complexes in Genome Organization, Function and Maintenance (Hardcover, 1st ed. 2018)
Expected to ship within 10 - 15 working days
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The three-dimensional organization of the DNA inside the eukaryotic
cell nucleus has emerged a critical regulator of genome integrity
and function. Increasing evidence indicates that nuclear pore
complexes (NPCs), the large protein channels that connect the
nucleus to the cytoplasm, play a critical role in the establishment
and maintenance of chromatin organization and in the regulation of
gene activity. These findings, which oppose the traditional view of
NPCs as channels with only one: the facilitation of
nucleocytoplasmic molecule exchange, have completely transformed
our understanding of these structures. This book describes our
current knowledge of the role of NPCs in genome organization and
gene expression regulation. It starts by providing an overview of
the different compartments and structures of the nucleus and how
they contribute to organizing the genome, then moves to examine the
direct roles of NPCs and their components in gene expression
regulation in different organisms, and ends by describing the
function of nuclear pores in the infection and genome integration
of HIV, in DNA repair and telomere maintenance, and in the
regulation of chromosome segregation and mitosis. This book
provides an intellectual backdrop for anyone interested in
understanding how the gatekeepers of the nucleus contribute to
safeguarding the integrity and function of the eukaryotic genome.
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