This collection of robust, readily reproducible methods for
microarray-based studies includes expert guidance in the optimal
data analysis and informatics. On the methods side are proven
techniques for monitoring subcellular RNA localization en masse,
for mapping chromosomes at the resolution of a single gene, and for
surveying the steady-state genome-wide distribution of DNA binding
proteins in vivo. For those workers dealing with massive data sets,
the book discusses the methodological aspects of data analysis and
informatics in the design of microarray experiments, the choice of
test statistic, and the assessment of observational significance,
data reduction, and clustering.
General
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