Much research has attempted to show direct linear relations between
genes and disorder. However, scientists have been discouraged by
inconsistent findings based on this simple gene-phenotype approach.
The alternative approach is to incorporate information about the
environment. A gene-environment interaction approach assumes that
environmental pathogens cause disorder, whereas genes influence
susceptibility to environmental pathogens. This book brings
together contributions from experts from multiple disciplines who
discuss:* How epidemiological cohort studies can better integrate
physiological (mechanistic) measures;* How best to characterise
subjects' vulnerability versus resilience by moving beyond single
genetic polymorphisms;* How gene hunters can benefit from
recruiting samples selected for known exposures;* How environmental
pathogens can be used as tools for gene hunting;* How to deal with
potential spurious (statistical) interactions, and* How genes can
help explain fundamental demographic properties of disorders (e.g.
sex distribution, age effects).
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