The Leading Introduction to Biochemical and Bioprocess Engineering,
Updated with Key Advances in Productivity, Innovation, and Safety
Bioprocess Engineering, Third Edition, is an extensive update of
the world's leading introductory textbook on biochemical and
bioprocess engineering and reflects key advances in productivity,
innovation, and safety. The authors review relevant fundamentals of
biochemistry, microbiology, and molecular biology, including
enzymes, cell functions and growth, major metabolic pathways,
alteration of cellular information, and other key topics. They then
introduce evolving biological tools for manipulating cell biology
more effectively and to reduce costs of bioprocesses. This edition
presents major advances in the production of biologicals; highly
productive techniques for making heterologous proteins; new
commercial applications for both animal and plant cell cultures;
key improvements in recombinant DNA microbe engineering; techniques
for more consistent authentic post-translational processing of
proteins; and other advanced topics. It includes new, improved, or
expanded coverage of The role of small RNAs as regulators
Transcription, translation, regulation, and differences between
prokaryotes and eukaryotes Cell-free processes, metabolic
engineering, and protein engineering Biofuels and energy, including
coordinated enzyme systems, mixed-inhibition and enzyme-activation
kinetics, and two-phase enzymatic reactions Synthetic biology The
growing role of genomics and epigenomics Population balances and
the Gompetz equation for batch growth and product formation
Microreactors for scale-up/scale-down, including rapid scale-up of
vaccine production The development of single-use technology in
bioprocesses Stem cell technology and utilization Use of
microfabrication, nanobiotechnology, and 3D printing techniques
Advances in animal and plant cell biotechnology The text makes
extensive use of illustrations, examples, and problems, and
contains references for further reading as well as a detailed
appendix describing traditional bioprocesses.
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