Researchers in structural genomics continue to search for
biochemical and cellular functions of proteins as well as the ways
in which proteins assemble into functional pathways and networks
using either experimental or computational approaches. Based on the
experience of leading international experts, Structural Genomics
and High Throughput Structural Biology details state-of-the-art
analytical and computational methods used to reveal the
three-dimensional structure and function of proteins.
A historical perspective and a detailed guide to the production
of protein material for structural determination, a key step in the
process, lay the necessary foundation for discussing the most
effective structure determination technologies, such as X-ray
crystallography and NMR spectroscopy. Encouraging the study of
genes and proteins of unknown structure in order to discover new
information about folding, specific structural features, or
function, Structural Genomics and High Throughput Structural
Biology presents the methods used to interpret the sequences of
proteins in a structural context, giving insight into their
function. It also explains how to extract information from public
data repositories and how to account for variability and accuracy
in the quality of this data.
The book concludes with a discussion of practical applications
of therapeutically driven structural genomics, and presents future
directions in the field. Structural Genomics and High Throughput
Structural Biology offers a comprehensive guide to the theoretical,
technological, and experimental methodologies used to derive
structural information from encoded proteins by renowned and world
leading scientists in the field.
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