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Interferon beta 1 gene and human cancer (Paperback)
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Interferon beta 1 gene and human cancer (Paperback)
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Cancer is an un-control growth of cells. Cancer cells grow in an
abnormal fashion, crowd out the normal cells. Liver is the largest
organ inside the body; hepatocellular carcinoma is a cancer arising
from liver. Laryngeal cancer affects the larynx, which is often
called voice box, common in males. Lung cancer is the deadliest
cancer in the world, leading cause of death from cancer in men.
Multiple gene mutations are involved in cancer pathology. Type I
interferons (IFN, IFN, IFN ) are the proteins involved in cell
signaling and growth. This study was conducted to determine whether
mutation in IFN 1 plays a significant role in liver, larynx and
lung cancer. Paraffin embedded tissues of liver, larynx and lung
were used for DNA isolation. SSCP technique was used to detect
mutation. Only two samples of lung carcinoma shows the mobility
shift on SSCP gel. It was observed that people in older age have
more chances of cancer. In general population, males are more prone
to larynx and lung cancer than female. Significant values were
observed (p
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