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Doubly Substituted Tyrosine Derivatives - Biologically Active Molecules (Paperback)
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Doubly Substituted Tyrosine Derivatives - Biologically Active Molecules (Paperback)
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This Book describes the synthesis, crystal structure determination,
antibacterial, antifungal, Brine-Shrimp Cytotoxocity assay and DPPH
antioxidants studies of a range of new N- & O-Sulphonated
derivatives of tyrosine. The targeted compounds were prepared by
the reaction of Tyrosine with different sulfonyl chlorides via
different synthesis schemes from moderate to excellent yields. The
final products were extensively screened to investigate their
antibacterial and antifungal potentials. All the derivatives were
found to be active against Staphylococcus aureus, Micrococcus
luteus, Escherichia coli, Bacillus broncistepica, Salmonella
typhimurium and Enterobacter aerogenes. These Derivative did not
show any bioactivity against fungal strains such as Mucor species,
Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus and
Fusarium solani. The targeted compounds were also subjected to
Brine-Shrimp cytotoxic studies. Only one compound showed good
cytotoxic activity while other derivatives exhibit no activity at
all.Antioxidant potential of these derivatives was investigated by
DPPH Assay. All compounds showed excellent antioxidant activities.
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