"Research Advances in Genetics and Genomics: Implications for
Psychiatry" introduces mental health professionals to exciting
breakthroughs in endophenotypes, animal models, microarrays, and
genetic mapping, as well as general strategies for identifying the
genetic mechanisms of mental illnesses.
Uniquely valuable both as summary and signpost, this concise
volume provides a fascinating overview of recent cutting-edge
developments in the application of molecular genetics, genomics,
and proteomics to the study of psychiatric populations.
By reading "Research Advances in Genetics and Genomics," you
will gain a better understanding of "Psychiatric Genetics"&
mdash;Reviews and assesses the major research paradigms that have
emerged in the field of psychiatric genetics over the several past
decades, exploring the major conceptual and philosophical issues
they pose and the value of their integration. "Molecular Structure
of Nucleic Acids"& mdash;An overview of the double-helix
discovery and provides a context for current endeavors, the
original one-page April 1953 Nature paper by Watson and Crick,
which sparked a revolution in the life sciences. "Psychiatry in the
Genomics Era"& mdash;Posits that one of the most important
consequences of genomics will be the development of individualized
treatments that allow a clinician to tailor therapy on the basis of
the unique genotype of each patient rather than on the mean
responses of groups of unrelated patients. "The Genomics
Revolution"& mdash;Details the implications of the genome for
future medical practice, including the potential for developing
methods and tools to better understand, treat, and prevent major
mental disorders. "TheEndophenotype Concept in Psychiatry"&
mdash;Explains the etymology and strategy behind the use of
endophenotypes in neuropsychiatric research and, more generally, in
research on other diseases with complex genetics, such as
schizophrenia. "The Genes and Brains of Mice and Men"&
mdash;Shows why a detailed assessment of brain function in mice is
so important for advancing psychiatric research in humans. Humans
and mice share numerous features-in fact, for an estimated 99% of
human genes a mouse version may be identified-of brain organization
and behavioral responses to many pharmacological agents.
"Microarray Technology"& mdash;Asserts that microarrays present
a methodology for identifying genes or pathways for new and unique
potential drug targets, determining premorbid diagnosis, predicting
drug responsiveness for individual patients, and, eventually,
initiating gene therapy and prevention strategies.
Meticulously referenced, this volume is exceptionally useful as
a starting point for understanding the impact of genetics and
genomics on psychiatry, serving to introduce psychiatrists,
psychologists, neurologists, and geneticists to this exciting
field.
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