Drug research encompasses several diverse disciplines united by a
common goal, namely the development of novel therapeutic agents.
The search for new drugs can be divided functionally into two
stages: discovery and development. The former consists of setting
up a working hypothesis of the target enzyme or receptor for a
particular disease, establishing suitable models (or surrogate
markers) to test biological activities, and screening the new drug
molecules for in vitro and/or in vivo biological activities. In the
development stage, efforts are focused on evaluation of the
toxicity and efficacy of new drug candidates.Recent surveys
indicate that the average new chemical entity taken to market in
the United States requires 10 to 15 years of research and costs
more than $300 million. Once the target enzyme or receptor is
identified, medicinal chemists use a variety of empirical and
semiempirical structure-activity relationships to modify the
chemical structure of a compound to maximize its in vitro activity.
General
Imprint: |
VDM Verlag
|
Country of origin: |
Germany |
Release date: |
June 2011 |
First published: |
June 2011 |
Authors: |
Narendra Singh Lodhi
|
Dimensions: |
229 x 152 x 17mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
288 |
ISBN-13: |
978-3-639-36362-3 |
Categories: |
Books >
Medicine >
General issues >
General
|
LSN: |
3-639-36362-0 |
Barcode: |
9783639363623 |
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