Potential Risks and Benefits of Gain-of-Function Research - Summary of a Workshop (Paperback)

On October 17, 2014, spurred by incidents at U.S. government laboratories that raised serious biosafety concerns, the United States government launched a one-year deliberative process to address the continuing controversy surrounding so-called "gain-of-function" (GOF) research on respiratory pathogens with pandemic potential. The gain of function controversy began in late 2011 with the question of whether to publish the results of two experiments involving H5N1 avian influenza and continued to focus on certain research with highly pathogenic avian influenza over the next three years. The heart of the U.S. process is an evaluation of the potential risks and benefits of certain types of GOF experiments with influenza, SARS, and MERS viruses that would inform the development and adoption of a new U.S. Government policy governing the funding and conduct of GOF research. Potential Risks and Benefits of Gain-of-Function Research is the summary of a two-day public symposia on GOF research. Convened in December 2014 by the Institute of Medicine and the National Research Council, the main focus of this event was to discuss principles important for, and key considerations in, the design of risk and benefit assessments of GOF research. Participants examined the underlying scientific and technical questions that are the source of current discussion and debate over GOF research involving pathogens with pandemic potential. This report is a record of the presentations and discussion of the meeting. Table of Contents Front Matter 1 Introduction 2 Assessing Risks and Benefits 3 Gain-of-Function Research: Background and Alternatives 4 Potential Benefits of Gain-of-Function Research 5 Potential Risks: Biosafety and Biosecurity 6 Policy Implications References Appendix A: Key Issues for Risk/Benefit Assessment for Gain-of-Function Research Appendix B: Committee Biographies Appendix C: Agenda Appendix D: Speaker Biographies Appendix E: List of Attendees Appendix F: Acronym List

General

Imprint:	National Academies Press
Country of origin:	United States
Release date:	May 2015
First published:	2015
Authors:	National Research Council • Institute of Medicine • Board on Health Sciences Policy • Policy and Global Affairs • Committee on Science, Technology, and Law • Division on Earth and Life Studies • Board on Life Sciences
Editors:	India Hook-Barnard • Audrey Thevenon • Anne-Marie Mazza
Dimensions:	229 x 152mm (L x W)
Format:	Paperback
Pages:	140
ISBN-13:	978-0-309-36783-7
Categories:	Books > Medicine > General Books > Science & Mathematics > Science: general issues > General Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Bio-ethics
LSN:	0-309-36783-2
Barcode:	9780309367837

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