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Books > Medicine > General issues > Medical ethics
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Animal Models in Light of Evolution (Paperback)
Loot Price: R1,882
Discovery Miles 18 820
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Animal Models in Light of Evolution (Paperback)
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The central concern of this book is with the "prediction problem"
in biomedical research. In particular, the authors examine the use
of animal models to predict human responses in drug and disease
research. The arguments discussed are drawn from both biological
and biomedical theory (with numerous examples and case studies
drawn from evolutionary biology, complex systems theory, oncology,
teratology, and AIDS research), and analyses of empirical evidence
(concerning, for example, data on intra- and inter-species
differences revealed by recent results from genome analyses of
various species, human population studies, and statistical studies
of the predictive utility of animal models). This book comes to the
unique conclusion that while animals can be successfully used for
many endeavors in science such as basic and comparative research,
they cannot be used to predict drug and disease response in humans.
The arguments presented are rooted in the history, philosophy, and
methodology of biomedical research. This book will be of interest
to anyone involved, directly or indirectly, in biomedical research
(including physicians, veterinarians and scientists), and anyone
interested in the history, philosophy and methodology of science.
In contrast to books written by and for the animal rights movement
and books written by and for the animal-based research industry,
this book honestly examines all sides of the scientific arguments
for using animals in science and concludes that each group in turn
exaggerates the flaws or strengths of using animals. There are
areas in science where animals can be viably used but there are
also areas where they cannot be so used.
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