The I. Beritashvili Center of Experimental Biomedicine was
established in 2010 on the basis of merging four well-known
Georgian research institutes. They are: The I. Beritashvili
Institute of Physiology, one of the most prominent research centers
of Georgia, where basic and applied research in different fields of
neurophysiology has been conducted since 1935; the Institute of
Molecular Biology and Biophysics; the Center for Radiology and
Radiation Ecology, which for many years operated as departments at
the I. Beritashvili Institute of Physiology; and one of the leading
research centers for Georgia: The Center of Experimental Neurology.
This edited book is the second volume containing chapters
constituting the research priorities of the I. Beritashvili Center
of Experimental Biomedicine and covers the experimental study of
fundamental issues in the functioning of physiological (mainly,
neurophysiological) mechanisms during normal and pathological
conditions. The first book Cellular and Molecular Mechanisms of
Physiological Functions and Their Disorders published by Nova
Science Publishers Inc. in 2015, was also devoted to the same
general problems. In the present edited book, particular attention
is drawn to the study of extremely important processes underlying
the basic mechanisms and disorders of various phenomenon of
integrative activity of the brain: General behavior, learning and
memory processes, the sleep-wakefulness cycle, regulation of
adequate blood supply, hormesis, vision, depression, experimental
comatose state, epilepsy, tumor diseases, pain and analgesia, the
state of anxiety and aggression. All of the mentioned processes are
studied on the molecular, cellular and systemic levels of their
organization. It has to be noted herewith that each chapter within
the collection of works represents the results of separate,
independent studies implemented by different scientific departments
of the Center; therefore, the chapters are not directly related to
each other and have been arranged alphabetically based on the
surnames of the authors. The authors would like to take this
opportunity and present to the reader the scientific and
institutional infrastructure of the Center, which consists of
departments and laboratories. Nowadays, the Center is comprised of
seven departments: Neurophysiology, Membranology, Biochemistry,
Blood Circulation and Metabolism, Neurotoxicology, Biophysics and
Radiobiology and nine laboratories: Behavior and Cognitive
Functions, Physiology of Vision, Neurobiology of Sleep-Wakefulness
Cycle, Ultra- and Nanoarchitectonics of the Brain, Experimental
Neurology, Pain and Analgesia, Bioinformatics, Structure and
Function of Genomes, and the Problems of Radiation Safety. In
addition to bilateral scientific cooperation with many famous
European and American scientific institutions, the Center is a
member of the International Science Consortium From Molecular to
Cellular Events in Human Pathologies, of which the 2015 Annual
Meeting was held in Tbilisi. The authors are sure that readers are
fully aware of the theoretical and practical importance of the
research related to problems of systemic, cellular and molecular
mechanisms of physiological functions and their disorders. The
presented collection of works contains the results of relevant
research conducted over the last three years (2015-2018). The
authors will be very grateful for any feedback, recommendations and
suggestions regarding their research for the implementation of
which they have invested a lot of effort, time, knowledge and
experience.
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