Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis (Paperback, Softcover reprint of the original 1st ed. 2004)

There is now evidence that irreversible brain damage accumulates very early in the course of multiple sclerosis. This book reviews the main neurobiological, magnetic resonance imaging, and clinical aspects of the early phases of the dis ease. Mechanisms ofirreversible axonal damage and the role played by the inter action of glia and the axon are highlighted. In contrast to what was believed for a long time, the sufficient availability of oligodendrocyte precursor cells to promote remyelination in acute lesions has now been demonstrated. For reasons not understood, this remyelination process fails or does not start, particularly in the chronic stages ofthe disease. These findings emphasize the importance of the "milieu" changes induced by an inflammatory process in limiting remyelination. However, first indications are that part of this inflammatory process may have a neuroprotective effect. Pathological studies in multiple sclerosis have now clearly demonstrated that destructive processes may be followed by recovery phases in such a way that myelin may be morphologically and functionally reconstituted. These findings provide the rationale for early treatment and emphasize the importance of clinical trials in early multiple sclerosis. Early treatment is one of the most important aspects in multiple sclerosis today.

General

Imprint:	Springer-Verlag
Country of origin:	Italy
Series:	Topics in Neuroscience
Release date:	September 2012
First published:	2004
Authors:	O.R. Hommes • G. Comi
Dimensions:	235 x 155 x 12mm (L x W x T)
Format:	Paperback
Pages:	199
Edition:	Softcover reprint of the original 1st ed. 2004
ISBN-13:	978-88-470-2171-6
Categories:	Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology Books > Medicine > Other branches of medicine > Medical imaging > Radiology Promotions
LSN:	88-470-2171-5
Barcode:	9788847021716

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