In the last few years the major effect that RNAi has had in
invertebrate systems like C.elegans and drosophila is beginning to
take hold in mammalian systems through both single gene knockdown
experiments and genome-scale screens. In the next decade, there
will no doubt be both notable successes and failures as we attempt
to apply this genetic tool to various biological problems for the
first time in academia and industry. Through the introduction of
RNAi, mammalian systems have finally gained admittance to the
pantheon of model genetic systems.
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