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The Papovaviridae - The Papillomaviruses (Paperback, Softcover reprint of the original 1st ed. 1987)
Loot Price: R1,519
Discovery Miles 15 190
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The Papovaviridae - The Papillomaviruses (Paperback, Softcover reprint of the original 1st ed. 1987)
Series: The Viruses
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In recent years there has been an explosion in research on the
papillo- maviruses. The viral nature of human warts was first
suggested 80 years ago by Ciuffo, who demonstrated transmission
using cell-free filtrates. Shope described the first papillomavirus
over 50 years ago as the etiologic agent in infectious
papillomatosis in rabbits. Subsequent studies by Rous established
that benign rabbit papillomas induced by this virus could progress
to carcinomas when treated with specific nonviral cofactors.
Despite these rich beginnings, the papillomavirus field lay
virtually dor- mant until the late 1970s because no one was able to
propagate these viruses in culture successfully. In the late 1970s
the molecular cloning of the papillomavirus genomes permitted
investigators to partially cir- cumvent this obstacle to their
progress. The cloning of the viral genomes permitted the
standardization of viral reagents and provided sufficient material
to begin a systematic evaluation of the biology of this group of
viruses.
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