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Modulation of Host Gene Expression and Innate Immunity by Viruses (Hardcover, 2005 ed.)
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Modulation of Host Gene Expression and Innate Immunity by Viruses (Hardcover, 2005 ed.)
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This book is an excellent, up-to-date reference on a relatively
young area of research in which virology, cellular biology and
molecular pathogenesis govern the principles of coinvestigation.
Thus, the book will be of great interest to virologists, molecular
immunologists and biologists, and biochemists but also to clinical
pharmacologists in the long-term search for new antiviral agents.
Ulrich Desselberger, Gif-sur-Yvette/Cambridge. Infection of a naive
(non-immune) host with a virus elicits an immediate response which
results in a cascade of changes in the host, including an
interferon response (innate immunity). The outcome of this
interaction is influenced by the genes of the virus as well as the
genes of the host. Interestingly, different viruses do it in
different ways. Not only is there a plethora of mechanisms used by
the invading organisms, but the host has also evolved a great
variety of redundant and robust countermeasures. This interplay of
host and virus represents one of the most significant frontiers in
biology today. A clearer understanding of the mechanisms involved
will arm us with better strategies to deal with viruses, including
emerging pathogens and potential bioterrorism agents. This book is
sure to benefit students, scientists, and physicians working in the
areas of virology, immunology, microbiology, and infectious
diseases. Pharmaceutical industry professionals will also find
interest in this illuminating look into virus/host interactions.
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