Innumerable clinical problems have as their basis some derangement
in oxygen-dependent metabolism. To explore mechanisms of adjusting
to oxygen limitation, "Living without Oxygen" presents a bestiary
of exotic anaerobes that illuminate elements of metabolic
biochemistry only dimly seen in studies using standard experimental
animals. With their exaggerated anaerobic capabilities, Hochachka's
diving mammals, airbreathing fishes, and hypoxia-adapted lower
vertebrates allow a detailed assessment of what can and what cannot
be adjusted in the process of extending hypoxia tolerance. The book
places the enzymatic and biochemical machinery firmly in the
biological context and assumes only a modest familiarity with
bioenergetics and metabolic biochemistry. The author's clear prose
should make this technical presentation pleasantly unintimidating
for any physiologist, biochemist, or clinical investigator. The
insights of his unique approach make "Living without Oxygen"
essential reading.
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