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Cytoplasmic fate of messenger RNA (Paperback, Softcover reprint of the original 1st ed. 1997)
Loot Price: R2,773
Discovery Miles 27 730
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Cytoplasmic fate of messenger RNA (Paperback, Softcover reprint of the original 1st ed. 1997)
Series: Progress in Molecular and Subcellular Biology, 18
Expected to ship within 10 - 15 working days
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Total price: R2,793
Discovery Miles: 27 930
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Among all cellular RNA species of the three main types, ribosomal
RNA, transfer RNA or messenger RNA, be they from prokaryotic or
eukaryotic organisms, the prokaryotic mRNA is unique in that it has
no precursor and is synthesized in the same mature form as it is
translated into proteins. In fact, ribosomes join the nascent mRNA
chain and engage in protein synthesis long before its transcription
is complete. Provisions are even made for slowing down the ribo
somes at some sites to prevent them from catching up with the
RNA-polymerase. Of course, such a situation is only possible in the
prokaryotic world where there is no such thing as a nuclear mem
brane physically secluding the transcription process from the cy
toplasm where translation is restricted. Quite in the opposite
extreme, the eukaryotic pre-messenger RNA has to suffer many and
sometimes drastic steps of maturation (capping, polyadenylation,
splicing, edition) before the decision is made to export it to the
cytoplasm. That is where it enters the scope of this book. Once in
the cytoplasm, many options are still open to it: its entrance into
polysomes may be delayed (as it is in unfertilized eggs) or merely
prohibited (ferritin mRNA in iron-starved cells), directed to
specific locations within the cytoplasm or be more or less rapidly
degraded. During gametogenesis and early development, translational
control is probably the most significant level of gene expression."
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