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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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V(D)J Recombination (Paperback, 2009 ed.)
Loot Price: R4,549
Discovery Miles 45 490
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V(D)J Recombination (Paperback, 2009 ed.)
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v(D)J recombination: for the community of immunologists and
developmental biologists, the molecular route by which B and T
lymphocytes acquire their unique function of affording adaptive
immunity. Yet, for many-from experienced scientists to trainees-it
represents a (rather too) sophisticated process whose true insight
is excessively demanding. However, when not simplyconsidered as a
private ground for a few aficionados, it can be seen as a way of
understanding how maturelympho cytes carry on their basic
functions. For the group of aficionados-which includes this
editor-it is an elegant paradigm featuring many fascinating
evolutionary achievements of which the biological world alone has
the secret. These include a subtle biochemical principle most
likelyhijacked some 470 million years ago from an ancestral gene
invader and since then cleverly adapted by jawed vertebrates to
precisely cleave and rearrange their antigen receptor (Ig
andTCR)loci. This invader would itself have assigned the services
of the nonhomologous end joining (NHEJ) DNArepair machinery as well
as various DNApolymerases or transferases to work in concert with
developmental clues in lymphoid cell lineages to generate an immune
repertoire and efficient host surveillance while avoiding
autoimmunity. Recently, important new refinements in these systems
have emerged, continuing to challenge ourknowledge andbeliefs.
These arejust thetopics covered by the senior authors-all
established leaders in this field-and their colleagues, whilst
writing the various chapters in V(D)J Recombination.
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