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Regulation of Sertoli Cell and Germ Cell Differentiation (Paperback, 2005 ed.)
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Regulation of Sertoli Cell and Germ Cell Differentiation (Paperback, 2005 ed.)
Series: Advances in Anatomy, Embryology and Cell Biology, 181
Expected to ship within 10 - 15 working days
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Unwanted childlessness affects approximately one in six couples
worldwide. - though the exact proportion of the predominant cause
of the problem remains controversial, according to the World Health
Organization (WHO), in nearly 40% of cases the cause can be
attributed to the female, in 20% to the male, in 25% to both, and
in 15% the cause remains unknown. Based on these ?gures, the -
cidence of male factor infertility in the general population is
approximately 7%. The majority of these men, approximately 30%,
experience irreversible idiopathic infertility and cannot father
children without some form of medical intervention. Male factor
infertility, in addition, may be caused by testicular germ cell
cancer, which is known to represent the most common cancer among
young men, aged 15 to 35 years, in Western industrialized
countries. The number of affected men has increased dramatically
over the past 50 years. There is now growing evidence that human
testicular germ cell cancer originates from fetal germ cells
exhibiting an aberrant programme of gene expression, and tumour
progression may be favoured by an aberrant Sertoli cell-germ cell
communication.
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