A comprehensive multidisciplinary review of the most relevant
molecular, genetic, and behavioral approaches used to investigate
the neurobiological basis of drug addiction. The authors explore
the latest findings on opioid, psychostimulant, cannabinoid,
alcohol, and nicotine addiction, provide fresh insights into the
genetic basis of drug addiction and the new therapeutic
perspectives these have opened. They describe the technology
available to generate conditional knockout mice and show how these
mice can reveal the molecular basis of opioid, psychostimulant, and
cannabinoid addiction. They also review the different behavioral
models available to evaluate the rewarding effects of drugs and
analyze the genes involved in alcohol dependence.
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