COX-2 Blockade in Cancer Prevention and Therapy (Paperback, Softcover reprint of the original 1st ed. 2003)

The revelation that aspirin and aspirin-like compounds have notableantineo plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by which essential poly unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and cancer development, and its interruption by COX-2 inhibition, is elucidated. This is followed by a section on the epidemiology of NSAIDs and cancers of the colon and breast, and other anatomic sites. These chapters reflect significant cancer protection owing to the regular use of common NSAIDs such as aspirin and ibuprofen. A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings which show that COX-2 blocking agents produce striking chemopreventive effects against colon cancer and breast cancer as well as other malignancies. Genetic models are presented confirming the critical role of COX-2 in carcinogenesis. Section IV then discusses the molecular biology of COX -2 vis-a-vis the role of COX -2 and, to a lesser extent, COX -1, in modulating a number of important processes in molecular carcinogenesis such as mutagen esis, cell division, angiogenesis, cell differentiation, and apoptosis."

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Cancer Drug Discovery and Development
Release date:	November 2010
First published:	2003
Editors:	Randall E Harris
Dimensions:	254 x 178 x 20mm (L x W x T)
Format:	Paperback
Pages:	371
Edition:	Softcover reprint of the original 1st ed. 2003
ISBN-13:	978-1-61737-304-6
Categories:	Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General Promotions
LSN:	1-61737-304-4
Barcode:	9781617373046

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