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The Quasispecies Equation and Classical Population Models (Hardcover, 1st ed. 2022)
Loot Price: R3,897
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The Quasispecies Equation and Classical Population Models (Hardcover, 1st ed. 2022)
Series: Probability Theory and Stochastic Modelling, 102
Expected to ship within 12 - 19 working days
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This monograph studies a series of mathematical models of the
evolution of a population under mutation and selection. Its
starting point is the quasispecies equation, a general non-linear
equation which describes the mutation-selection equilibrium in
Manfred Eigen's famous quasispecies model. A detailed analysis of
this equation is given under the assumptions of finite genotype
space, sharp peak landscape, and class-dependent fitness
landscapes. Different probabilistic representation formulae are
derived for its solution, involving classical combinatorial
quantities like Stirling and Euler numbers. It is shown how
quasispecies and error threshold phenomena emerge in finite
population models, and full mathematical proofs are provided in the
case of the Wright-Fisher model. Along the way, exact formulas are
obtained for the quasispecies distribution in the long chain
regime, on the sharp peak landscape and on class-dependent fitness
landscapes. Finally, several other classical population models are
analyzed, with a focus on their dynamical behavior and their links
to the quasispecies equation. This book will be of interest to
mathematicians and theoretical ecologists/biologists working with
finite population models.
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