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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > Allergies
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Cystic Fibrosis - Infection, Immunopathology, and Host Response (Paperback, Softcover reprint of the original 1st ed. 1990)
Loot Price: R2,885
Discovery Miles 28 850
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Cystic Fibrosis - Infection, Immunopathology, and Host Response (Paperback, Softcover reprint of the original 1st ed. 1990)
Series: Allergy and Immunology, 1
Expected to ship within 10 - 15 working days
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This work is concerned with Cystic Fibrosis (CF), the most common
fatal genetic disease in the Caucasian population. The decade of
the 1980s was one of spectacular progress in understanding the
genetic and molecu lar basis of CF. The research breakthroughs of
the decade began with the first fundamental insights, published in
1981-1983, into the basic cellular pathophysiology of CF with
demonstrations of altered ion transport in spe cialized exocrine
epithelial tissues (1-3). Research progress shifted into a triumph
of "reverse genetics," using restriction-fragment-Iength polymor
phism DNA technology (4), with the localization of the CF gene to a
region of chromosome 7 (5-7). Understanding, accelerated by an
explOSion of in vitro methodologies for epithelial cell culture and
transformation, allowed and physiological studies (8-11); these
focused, controlled biochemical with increasing precision, on the
molecular pathology of distal steps in the regulatory pathways for
epithelial ion transport (12-19). Finally, the "end of the
beginning" occurred in late 1989 with one of the great achievements
of molecular genetics, the isolation and cloning of the CF gene
(20). As a result, we now have a CF gene product, the cystic
fibrosis transmembrane regulator (CFfR), possessing predicted amino
acid sequence, suggested tertiary structure, and possible
transmembrane transport function (21). These amazing developments
have set the stage for the next round of advances, which surely
will include: 1.
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