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Adaptive and Flexible Clinical Trials (Hardcover, New)
Loot Price: R2,944
Discovery Miles 29 440
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Adaptive and Flexible Clinical Trials (Hardcover, New)
Expected to ship within 12 - 17 working days
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Adaptive clinical trial designs, unlike traditional fixed clinical
trial designs, enable modification of studies in response to the
data generated in the course of the trial. This often results in
studies that are substantially faster, more efficient, and more
powerful. Recent developments in web-based real-time data entry and
advances in statistical methods have made adaptive clinical trials
much more popular because they have become both more practical and
attractive. However, there is paucity of resources that explain the
mathematical framework and the practical considerations for
adaptive designs without the use of highly technical statistical
jargon. Suitable for readers in academia, industry, and government
involved in drug development, Adaptive and Flexible Clinical Trials
is the first book that comprehensively explains all essential
aspects of adaptive clinical trials. Written in an
easy-to-understand style aimed at clinicians and other
non-statisticians, this book focuses not on the statistical
details, but rather on the application of statistical concepts for
adaptive clinical trials. Utilizing concrete examples, the book
thoroughly explains the design, conduct, and analysis of adaptive
and flexible clinical trials, allowing readers to select and design
the appropriate trial designs from a conceptual perspective. From
basic theory to real-life practical issues, it covers all aspects
of adaptive and flexible clinical trials, including regulatory
issues, interim analysis, adaptive dosing, and sequential designs.
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