Patients with a variety of tumors present to the physician because
of clinical manifestations of hormones secreted in excess. This
phenomenon attracted the investigative interest of such pioneers as
Harvey Cushing who recognized that pituitary tumors may cause
acromegaly and Charles Mayo who associated hyper tension with
adrenal medullary neoplasms. Current int rest in endocrine-related
tumors has intensified because of the explosive development of
newer methodol ogy for their study. Specific measurements of
secretory products, hybridization assays to identify products of
genomic translation and quantitative assessment of tissue hormone
receptors have provided means of characterizing and precisely
following patients with endocrine-related tumors. Treatments based
upon these advances are rapidly proliferating. The current volume
attempts to synthesize much of this recent information with the
goal of providing a sound basis for making clinical judgements
regarding diagnosis and management. Tumors of endocrine glandular
tissues commonly confront practicing physi cians with difficult
management problems. Several unique features of these tumors
necessitate collaboration among various specialty disciplines in
order to resolve these problems and to provide a high level of
clinical care. For example, endocrine neoplasms secrete active
hormones or hormone precursors which produce clinical
manifestations most familiar to endocrinologists. Certain thera
pies such as radioactive iodine for thyroid cancer take advantage
of the hormone responsiveness of these tumors to facilitate
treatment. These aspects require individuals trained in
endocrinology to implement complex diagnostic and thera peutic
maneuvers."
General
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