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Epidemiological Aspects of Cutaneous Malignant Melanoma (Hardcover, 1994)
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Epidemiological Aspects of Cutaneous Malignant Melanoma (Hardcover, 1994)
Series: Developments in Oncology, v. 73
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Significant progress has been made in recent years in understanding
the origins of cutaneous maligant melanoma. Knowledge of the
relationship between solar radiation and melanoma has changed and
it now appears that both the character and timing of exposure may
be more important than total cumulative dose in accounting for
risk. The melanoma-sunlight model may prove an instructive
heuristic exercise for environmental epidemiology, as we currently
tend to restrict ourselves to a search for uniform total
dose--response relationships between cancers and suspected
environmental carcinogens. The study of the relationship between
acquired melanocytic nevi and melanoma has led to useful new
information about predictors of melanoma risk, and in addition has
opened new perspectives on the development of nevi in children.
Definition of the factors for nevus development in children may
lead to the possibility of primary prevention programs for melanoma
in younger generations of children. Recent new evidence suggests
that certain occupational groups may be at elevated risk of
melanoma. A great deal of work is going into the study of ways of
screening high risk populations in order to detect melanoma at its
earliest stages when current treatment protocols are most
effective. The visibility of lesions on the skin challenges
classical definitions of early detection and screening in
epidemiology.
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