This authoritative overview on an emerging topic in the molecular
life sciences covers all aspects of the aging of (long-lived)
proteins. It describes the molecular mechanisms of aging on the
protein level, in particular the most common side chain
modifications and includes analytical methods to study protein
half-life and the accumulation of modifications. Finally, the
impact of protein aging on several age-related disases in humans is
dissected, and their role in limiting human lifespan is discussed.
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