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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Signaling Pathways for Translation - Insulin and Nutrients (Hardcover, 2001 ed.)
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Signaling Pathways for Translation - Insulin and Nutrients (Hardcover, 2001 ed.)
Series: Progress in Molecular and Subcellular Biology, 26
Expected to ship within 9 - 15 working days
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The articles in the present volume are by major contributors to our
under standing of signaling pathways affecting protein synthesis.
They focus pri marily on two extracellular anabolic signals,
although others are included as well. Insulin is one of the
best-studied extracellular regulators of protein syn thesis.
Several of the known pathways for regulation of protein synthesis
were elucidated using insulin-dependent systems. Regulation of
protein synthesis by amino acids, by contrast, is an emerging field
that has recently received a great deal of attention. The dual role
of amino acids as substrates for protein syn thesis and regulators
of the overall process has only recently been recognized. Since
amino acids serve as precursors for proteins, one might expect that
with holding an essential amino acid would inhibit the elongation
phase. Surpris ingly, research has shown that it is the initiation
phase of protein synthesis that is restricted during amino acid
starvation. Understanding the mechanisms by which the biosynthesis
of proteins is reg ulated is important for several reasons. Protein
synthesis consumes a major portion of the cellular ATP that is
generated. Therefore, small changes in protein synthesis can have
great consequences for cellular energy metabolism. Translation is
also a major site for control of gene expression, since messenger
RNAs differ widely in translational efficiency, and changes to the
protein syn thesis machinery can differentially affect recruitment
of individual mRNAs."
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