This book explores the methionine dependence of cancer and its
effects on aging, a great story of science that is not widely
known. The chapters in this book describe the discovery of
methionine dependence of cancer; the molecular basis for the
increased methionine demand of cancer cells and tumors; the
clinical application of methionine dependence of cancer in PET
imaging with [11C]methionine; the development of methioninases as
cancer drugs; the anti-aging and anti-diabetes effects of
methionine restriction; and the future of targeting methionine in
the body for the elimination of cancer and for the extension of a
healthy life-span. Written in the highly successful Methods in
Molecular Biology series format, chapters include introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and thorough, Methionine Dependence of Cancer and
Aging: Methods and Protocols is an important resource for
researchers and scientists wishing to pursue this exciting and
vital area of study."
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