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Books > Medicine > Clinical & internal medicine > Haematology
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Blood Substitutes - New Challenges (Hardcover, 1996 ed.)
Loot Price: R2,562
Discovery Miles 25 620
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Blood Substitutes - New Challenges (Hardcover, 1996 ed.)
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Although blood substitutes represent a goal that has been sought
for more than a century, their development is now on the cutting
edge of biotechnology: beyond biochemistry and molecular biology,
these products are being integrated into the larger physiological
picture of gas transport that is essential to every living
organism. New products will find obvious clinical application,
since they overcome many of the problems with blood transfusion,
such as the need to crossmatch, storage limitations, and the risk
of transmission of infectious disease. As work continues to bring
this new class of products to market, discoveries have been made
about very basic aspects of how red blood cells work with regard to
the exchange of oxygen and carbon dioxide and interactions with
molecules such as nitric oxide and carbon monoxide which may
mediate contractility of smooth muscle. These new challenges are
being met with impressive rapidity as products are readied for
testing and introduction into clinical use. As more is understood
about the general properties of artificial blood substitutes,
attention is focusing on applications which will benefit the most
from their availability. This volume is a collection of chapters by
researchers currently working in the field of blood substitutes and
closely related fields. Each of them focuses on current challenges
from a different perspective, from the clinical question, "What is
the target?", to detailed descriptions of the interactions with
nitric oxide, endotoxin, and carbon dioxide. Included in the volume
is a review of the peer-reviewed research published in 1995 and a
general discussion of current products and potential clinical
applications. Takentogether, these chapters provide an up-to-date
picture of this rapidly evolving field.
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