The year 2010 marks the centennial for the identification of
histamine and the first glimpse of its many physiological
functions. From these initial findings a rich tapestry of research
has uncovered roles for histamine in almost every physiological
process with new findings emerging every year. These diverse roles
of histamine have made for fertile ground for the discovery of
novel therapeutics, and these drugs have been so successful that
the term "antihistamine" has entered the common lexicon. This
volume is an attempt to give a snapshot in time as to the current
understanding of the role of histamine in just one important
therapeutic area-inflammation. The first three chapters provide
some background context for the rest of the book starting out with
a historical perspective by Figueroa and Shankley. Bongers et al
provide an overview of the pharmacology of the four histamine
receptors and the chapter by Hiroshi Ohtsu describes how histamine
is synthesized as well as the insights derived from mice where this
synthesis is disrupted. The next several chapters discuss disease
areas where histamine is known to be involved. Chapter 4 by Thomas
Taylor-Clark outlines the role of histamine in allergic rhinitis,
an area were antihistamines are commonly used. This is also true
for ocular allergy as discussed by Ohbayashi et al. Both of these
chapters highlight aspects of these conditions that are still not
well-controlled and suggest the utility of new antihistamines
targeting other histamine receptors.
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