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Bioelectricity - A Quantitative Approach (Hardcover, 1988 ed.)
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Bioelectricity - A Quantitative Approach (Hardcover, 1988 ed.)
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This text is an introduction to electrophysiology, following a
quantitative approach. The first chapter summarizes much of the
mathematics required in the following chapters. The second chapter
presents a very concise overview of the general principles of
electrical fields and current flow, mostly es tablished in physical
science and engineering, but also applicable to biolog ical
environments. The following five chapters are the core material of
this text. They include descriptions of how voltages come to exist
across membranes and how these are described using the Nernst and
Goldman equations (Chapter 3), an examination of the time course of
changes in membrane voltages that produce action potentials
(Chapter 4), propagation of action potentials down fibers (Chapter
5), the response of fibers to artificial stimuli such as those used
in pacemakers (Chapter 6), and the voltages and currents produced
by these active processes in the surrounding extracellular space
(Chapter 7). The subsequent chapters present more detailed material
about the application of these principles to the study of cardiac
and neural electrophysiology, and include a chapter on recent
developments in mem brane biophysics. The study of
electrophysiology has progressed rapidly because of the precise,
delicate, and ingenious experimental studies of many investigators.
The field has also made great strides by unifying the numerous
experimental observations through the development of increasingly
accurate theoretical concepts and mathematical descriptions. The
application of these funda mental principles has in turn formed a
basis for the solution of many different electrophysiological
problems."
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